MOTS-c is supplied as a catalogued research material in 10 mg.
MOTS-c is a defined 16-residue mitochondrial-derived peptide. Formula, CAS and PubChem data apply only when the batch confirms the exact human sequence, free termini and supplied salt form [1].
Chemical properties and registry information
| Property | Value |
|---|---|
| Name and synonyms | Mitochondrial-derived peptide, MOTS-c(human) |
| Material category | Mitochondrial Peptide |
| Sequence | H-MRWQEMGYIFYIKNKER-OH |
| Molecular formula | C96H149N27O24S2 |
| Average molecular mass | 2129.5 g/mol |
| CAS Registry Number | 1627580-64-6 |
| PubChem CID | CID 91850911 |
| Structural features | A 16-amino acid linear peptide derived from the short open reading frame of the mitochondrial 12S rRNA gene. |
| Appearance | White to off-white lyophilised powder |
| Solubility | Reconstitute with 0.6% acetic acid in sterile water for best results. May also be soluble in sterile water, but can be prone to aggregation. |
| Physical form | Catalogue vial; exact salt/counter-ion and excipients are batch-specific and must be verified in the CoA and SDS. |
Registry values apply only to the specific molecular entity, sequence, termini and material form. Batch records take precedence over family-level literature identifiers.
A mitokine that regulates metabolic functions, including insulin sensitivity and glucose metabolism, acting as an exercise mimetic.
Research background and published evidence
Published research
Published MOTS-c work examines mitochondrial communication, metabolic-stress responses and AMPK-associated signaling, principally in cell and animal models [2,3].
Current scientific understanding
The directly relevant mechanistic evidence is predominantly preclinical and does not establish human safety or efficacy. Endogenous-sequence studies also do not authenticate the identity or quality of this synthetic catalogue batch.
An endogenous human sequence and a synthetic catalogue peptide are not automatically analytically or legally equivalent.
Technical comparison
| Aspect | This catalogue material | Comparator |
|---|---|---|
| Identity | Catalogue MOTS-c material, subject to sequence and exact-form batch confirmation | Exact human MOTS-c free-peptide reference standard |
| Structural distinction | Counter-ion, hydration, termini and nominal content remain batch-specific | Defined 16-residue sequence with free N and C termini |
| Analytical implication | Confirm full sequence, intact mass, termini, counter-ion and analyte content | Reference identifiers apply only when the synthetic batch matches the exact human free peptide |
Quality and testing
Quality information is batch- and presentation-specific. Use only the report linked to the exact size and lot. A report listed for another size, lot or similarly named material must not be treated as evidence for this product.
Chromatographic area purity, identity, net peptide or analyte content, water or counter-ion content, sterility, endotoxin and elemental impurities are different measurements. One result does not establish the others. Only tests supported by a visible, matching report should be regarded as available.
Laboratory handling and storage
Store and handle only under the conditions stated on the product label, batch CoA and SDS. Keep the container secured, correctly identified and protected from contamination. Do not infer storage, solvent compatibility or stability from a related compound.
Laboratory preparation, analytical-method selection, risk assessment, personal protective equipment and waste disposal should follow the applicable SDS and the institution’s approved procedures.
Regulatory and legal status
| Research-use notice | This material is supplied exclusively for laboratory research by qualified professionals and is not intended for human or veterinary use. Purchasers are responsible for compliance with applicable local requirements. |
Sources and references
- [1] PubChem. Human MOTS-c, CID 155885767.
- [2] Lee et al. MOTS-c is a mitochondrial-encoded peptide regulating metabolic homeostasis. Cell Metabolism (2015).
- [3] Kim et al. MOTS-c translocation and stress-responsive nuclear signaling. Cell Metabolism (2018).
Frequently Asked Questions
Do the CAS number and PubChem CID apply to every batch form?
Only when the exact sequence or structure, termini, conjugation, salt or counter-ion and hydration state match. The batch CoA and SDS govern; a related-compound identifier must not be substituted.
What does an analytical purity result mean?
It is method- and report-specific. For example, an HPLC area percentage is not automatically the same as identity, net content, sterility, endotoxin status or absence of elemental impurities.
How should the material be stored and handled?
Follow the exact label, batch CoA and SDS together with the institution’s risk assessment. Use only storage and stability information linked to the exact material form and batch.
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