5-Amino-1MQ is supplied as a catalogued research material in 50 mg.
“5-Amino-1MQ” identifies a quinolinium cation but does not define the counter-ion or hydration state of the supplied material. Formula, mass and registry identifiers must therefore be assigned from the exact batch documentation [1–3].
Chemical properties and registry information
| Property | Value |
|---|---|
| Name and synonyms | 5-amino-1-methylquinolinium |
| Material category | NNMT Inhibitor |
| Sequence | 5-amino-1-methylquinolin-1-ium |
| Molecular formula | C10H11N2 |
| Average molecular mass | 159.21 g/mol |
| PubChem CID | CID 139034101 |
| Structural features | Small molecule NNMT inhibitor; Quaternary quinolinium compound. |
| Appearance | White to off-white powder |
| Solubility | Soluble in DMSO. Water solubility is variable and may be limited depending on the specific salt form. |
| Physical form | Catalogue vial; exact salt/counter-ion and excipients are batch-specific and must be verified in the CoA and SDS. |
Registry values apply only to the specific molecular entity, sequence, termini and material form. Batch records take precedence over family-level literature identifiers.
A small molecule inhibitor of Nicotinamide N-methyltransferase (NNMT). The product is a salt (e.g., chloride or iodide), but the specific counter-ion is often not specified. Chemical data provided is for the 5-amino-1-methylquinolinium cation.
Research background and published evidence
Published research
Published work uses 5-amino-1-methylquinolinium salts as nicotinamide N-methyltransferase research inhibitors in enzyme, cell and mouse models [4].
Current scientific understanding
The directly relevant evidence is preclinical and does not establish human safety or efficacy. Literature material also does not authenticate the identity, counter-ion or composition of this catalogue batch.
A cation, iodide, chloride and hydrated salt are analytically distinct forms; their identifiers and masses are not interchangeable.
Technical comparison
| Aspect | This catalogue material | Comparator |
|---|---|---|
| Identity | Catalogue name with counter-ion and hydration state not yet confirmed | Reference 5-amino-1-methylquinolinium iodide with a defined hydration state |
| Structural distinction | Exact salt form cannot be inferred from “5-Amino-1MQ” alone | Iodide counter-ion and hydration are explicitly defined |
| Analytical implication | Confirm counter-ion, hydration and intact identity before assigning mass or registry data | Expected composition and mass are specific to the documented iodide form |
Quality and testing
Quality information is batch- and presentation-specific. Use only the report linked to the exact size and lot. A report listed for another size, lot or similarly named material must not be treated as evidence for this product.
Chromatographic area purity, identity, net peptide or analyte content, water or counter-ion content, sterility, endotoxin and elemental impurities are different measurements. One result does not establish the others. Only tests supported by a visible, matching report should be regarded as available.
Laboratory handling and storage
Store and handle only under the conditions stated on the product label, batch CoA and SDS. Keep the container secured, correctly identified and protected from contamination. Do not infer storage, solvent compatibility or stability from a related compound.
Laboratory preparation, analytical-method selection, risk assessment, personal protective equipment and waste disposal should follow the applicable SDS and the institution’s approved procedures.
Regulatory and legal status
| Research-use notice | This material is supplied exclusively for laboratory research by qualified professionals and is not intended for human or veterinary use. Purchasers are responsible for compliance with applicable local requirements. |
Sources and references
- [1] PubChem. 5-Amino-1-methylquinolinium, CID 950107.
- [2] PubChem. 5-Amino-1-methylquinolinium iodide, CID 66522933.
- [3] Tocris. Lot certificate for an NNM-TI iodide hemihydrate reference material.
- [4] Neelakantan et al. Selective inhibition of NNMT in preclinical models. Scientific Reports (2018).
Frequently Asked Questions
Do the CAS number and PubChem CID apply to every batch form?
Only when the exact sequence or structure, termini, conjugation, salt or counter-ion and hydration state match. The batch CoA and SDS govern; a related-compound identifier must not be substituted.
What does an analytical purity result mean?
It is method- and report-specific. For example, an HPLC area percentage is not automatically the same as identity, net content, sterility, endotoxin status or absence of elemental impurities.
How should the material be stored and handled?
Follow the exact label, batch CoA and SDS together with the institution’s risk assessment. Use only storage and stability information linked to the exact material form and batch.
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