KPV is supplied as a catalogued research material in 10 mg.
The registry assignment above is for H-KPV-OH. KPV-NH2, an acetate or trifluoroacetate salt, and KPV embedded within alpha-MSH are distinct exact forms and must not inherit these identifiers without confirmation.
Chemical properties and registry information
| Property | Value |
|---|---|
| Name and synonyms | Lys-Pro-Val, Lysyl-prolyl-valine |
| Material category | Anti-inflammatory peptide |
| Sequence | H-KPV-OH |
| Molecular formula | C16H30N4O4 |
| Average molecular mass | 342.44 g/mol |
| CAS Registry Number | 68461-36-9 |
| PubChem CID | CID 219045 |
| Structural features | Linear tripeptide, C-terminal fragment of alpha-Melanocyte-Stimulating Hormone (α-MSH). |
| Appearance | White to off-white lyophilised powder |
| Solubility | Readily soluble in water. |
| Physical form | Catalogue vial; exact salt/counter-ion and excipients are batch-specific and must be verified in the CoA and SDS. |
Registry values apply only to the specific molecular entity, sequence, termini and material form. Batch records take precedence over family-level literature identifiers.
A tripeptide with potent anti-inflammatory properties, acting independently of melanocortin receptors.
Research background and published evidence
Published research
KPV has been examined in cell and mouse models addressing melanocortin-related signalling, epithelial responses and inflammatory assay endpoints. Experimental interpretation depends on chemical form, concentration, model and matrix.
Current scientific understanding
The cited findings are preclinical, do not authenticate this batch and do not establish human-use outcomes. Results for full-length alpha-MSH or an amidated KPV form cannot be transferred to free-acid KPV without direct comparability.
Technical comparison
| Aspect | This catalogue material | Comparator |
|---|---|---|
| Identity | H-Lys-Pro-Val-OH, free-acid tripeptide | Alpha-MSH: acetylated, amidated 13-residue peptide ending in KPV-NH2 |
| Structural distinction | Three-residue fragment lacking the central HFRW sequence of alpha-MSH | Full-length alpha-MSH has additional sequence, N-acetylation and C-terminal amidation |
| Analytical implication | Confirm sequence, intact mass, purity, free-acid terminus and counter-ion | Fragment origin does not establish identity with alpha-MSH or with KPV-NH2 |
Quality and testing
Quality information is batch- and presentation-specific. Use only the report linked to the exact size and lot. A report listed for another size, lot or similarly named material must not be treated as evidence for this product.
Chromatographic area purity, identity, net peptide or analyte content, water or counter-ion content, sterility, endotoxin and elemental impurities are different measurements. One result does not establish the others. Only tests supported by a visible, matching report should be regarded as available.
Laboratory handling and storage
Store and handle only under the conditions stated on the product label, batch CoA and SDS. Keep the container secured, correctly identified and protected from contamination. Do not infer storage, solvent compatibility or stability from a related compound.
Laboratory preparation, analytical-method selection, risk assessment, personal protective equipment and waste disposal should follow the applicable SDS and the institution’s approved procedures.
Regulatory and legal status
| Research-use notice | This material is supplied exclusively for laboratory research by qualified professionals and is not intended for human or veterinary use. Purchasers are responsible for compliance with applicable local requirements. |
Sources and references
- [1] PubChem CID 125672 — Lys-Pro-Val
- [2] Gastroenterology — preclinical KPV study
- [3] Journal of Pharmacology and Experimental Therapeutics — KPV mechanistic study
- [4] Journal of Investigative Dermatology — KPV cell-model research
Frequently Asked Questions
Do the CAS number and PubChem CID apply to every batch form?
Only when the exact sequence or structure, termini, conjugation, salt or counter-ion and hydration state match. The batch CoA and SDS govern; a related-compound identifier must not be substituted.
What does an analytical purity result mean?
It is method- and report-specific. For example, an HPLC area percentage is not automatically the same as identity, net content, sterility, endotoxin status or absence of elemental impurities.
How should the material be stored and handled?
Follow the exact label, batch CoA and SDS together with the institution’s risk assessment. Use only storage and stability information linked to the exact material form and batch.
Reviews
There are no reviews yet.